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Browse result for Lysine Methylation
※ introduction protein lysine methylation, is a PTM involving the transfer of one, two or three methyl groups to the epsilon - amine of a lysine side chain. Lysine methylation represents a complex and often elusive PTM that has nonetheless the potential to alter the function of the modified protein. lysine methylation has been observed in both nuclear and cytoplasmic proteins and is now considered a prevalent modification in eukaryotes, prokaryotes and archaea. Two groups of enzymes, both using S - adenosyl - L - methionine (SAM) as a methyl donor, catalyze the addition of a methyl group to the epsilon - amine group of a lysine side chain. The first type of protein lysine methyltransferase regroups the enzymes containing a catalytic SET domain and the second class of PKMTs, the seven beta - strand methyltransferases (class I methyltransferases), belongs to an extended superfamily of methyltransferases found throughout eukaryotes, prokaryotes and archaea.
Reference
Pubmed: Lanouette S, Mongeon V, Figeys D, Couture JF. The functional diversity of protein lysine methylation. Mol Syst Biol. 2014 Apr 8;10:724. doi: 10.1002/msb.134974.
Reference
Pubmed: Lanouette S, Mongeon V, Figeys D, Couture JF. The functional diversity of protein lysine methylation. Mol Syst Biol. 2014 Apr 8;10:724. doi: 10.1002/msb.134974.
UniProt AC | Entrez ID | Gene Name | Protein Name | Organism |
---|---|---|---|---|
O43463 | 6839 | SUV39H1 | Histone-lysine N-methyltransferase SUV39H1 3-9 homolog 1) | Homo sapiens |
P03372 | 2099 | ESR1 | Estrogen receptor | Homo sapiens |
P04637 | 7157 | TP53 | Cellular tumor antigen p53 | Homo sapiens |
P05496 | 516 | ATP5G1 | ATP synthase F complex subunit C1, mitochondrial complex subunit C1) | Homo sapiens |
P06400 | 5925 | RB1 | Retinoblastoma-associated protein | Homo sapiens |
P09429 | 3146 | HMGB1 | High mobility group protein B1 | Homo sapiens |
P09874 | 142 | PARP1 | Poly [ADP-ribose] polymerase 1 ADP-ribosyltransferase 1) | Homo sapiens |
P0DMV8 | 3303 | HSPA1A | Heat shock 70 kDa protein 1A | Homo sapiens |
P10636 | 4137 | MAPT | Microtubule-associated protein tau | Homo sapiens |
P12004 | 5111 | PCNA | Proliferating cell nuclear antigen | Homo sapiens |
P17480 | 7343 | UBTF | Nucleolar transcription factor 1 | Homo sapiens |
P19838 | 4790 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] | Homo sapiens |
P22626 | 3181 | HNRNPA2B1 | Heterogeneous nuclear ribonucleoproteins A2/B1 | Homo sapiens |
P35918 | 16542 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus |
P35968 | 3791 | KDR | Vascular endothelial growth factor receptor 2 | Homo sapiens |
P40763 | 6774 | STAT3 | Signal transducer and activator of transcription 3 | Homo sapiens |
P49757 | 8650 | NUMB | Protein numb homolog | Homo sapiens |
P62805 | 8359 | HIST1H4A | Histone H4 | Homo sapiens |
P62807 | 8347 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | Homo sapiens |
P68431 | 8350 | HIST1H3A | Histone H3.1 | Homo sapiens |
Q01094 | 1869 | E2F1 | Transcription factor E2F1 | Homo sapiens |
Q01860 | 5460 | POU5F1 | POU domain, class 5, transcription factor 1 | Homo sapiens |
Q15910 | 2146 | EZH2 | Histone-lysine N-methyltransferase EZH2 | Homo sapiens |
Q9BXM7 | 65018 | PINK1 | Serine/threonine-protein kinase PINK1, mitochondrial | Homo sapiens |
Q9NS23 | 11186 | RASSF1 | Ras association domain-containing protein 1 | Homo sapiens |
Q9Y230 | 10856 | RUVBL2 | RuvB-like 2 (TIP60-associated protei | Homo sapiens |